The transcription factors Nrf2, STAT3, and SOX2 are multifunctional proteins [4], and several studies have shown that the abnormal expression of Nrf2, STAT3, and SOX2 can play a regulatory role in tumor proliferation and metastasis by interacting with different protein cofactors, including NSCLC, however, the role of Nrf2, STAT3, and SOX2 in NSCLC is still not well studied. Here, SOX2 is linked to neoplasm.