NES and non-small cell lung carcinoma: To determine the role of Nrf2 in Nestin-induced environment in response to oxidative stress, we used overexpression plasmid transfection to alter the expression levels of Nrf2 and Nestin in hNCSLC cells (Figure 5), and we obtained that Nestin maintains redox homeostasis in NSCLC cells by regulating antioxidant capacity.