SOX2 and non-small cell lung carcinoma: The transcription factors Nrf2, STAT3, and SOX2 are multifunctional proteins [4], and several studies have shown that the abnormal expression of Nrf2, STAT3, and SOX2 can play a regulatory role in tumor proliferation and metastasis by interacting with different protein cofactors, including NSCLC, however, the role of Nrf2, STAT3, and SOX2 in NSCLC is still not well studied.