This study aimed to determine the effect of enteral administration of Cucumis melo L.C. gliadin (CME-gliadin) to compare four groups of male Wistar rats, including negative and positive control rats and those supplemented with SOD CME-gliadin 1 IU/day and SOD CME-gliadin 5 IU/day as an antioxidant and anti-inflammatory in LPS-induced sepsis model rats. This evidence concerns the gene SOD1 and Sepsis.