Since the effect of MS on the decrease of reelin does not seem to interact with the lack of Mecp2, we suggest that MS might downregulate its expression in a pathway independent of the levels of Mecp2. Although not assessed in the present study, MS could be inducing DNA methylation at the promoter region of reelin, as it has been previously observed in other models of autism-like disorders and schizophrenia (Sánchez-Lafuente et al., 2022). Here, RELN is linked to schizophrenia.