NGF and hydrops fetalis: Increased TrkA nerve fiber density has been shown to be accompanied by increased NGF in the lumbar DRG in mice fed a HF diet for 12 weeks Thus, neuronal inflammation, via upregulation of NGF, may alter nociceptive input in the DRG by increasing TrkA nerve fiber density and lead to increased mechanical sensitivity in high fat diet-induced prediabetic models of PN.