Moreover, univariate analysis found that tumor location (P = 0.045), Lauren type (P = 0.045), Borrmann type (P = 0.002), N stage (P < 0.001), M stage (P < 0.001), the level of CEA (P < 0.001), the level of CA125 (P < 0.001), and TFR1 expression (P = 0.018) were the risk factors affecting the prognosis of GC. The gene discussed is TFRC; the disease is gastric cancer.