Moreover, the TFR1 expression was significantly associated with age (P = 0.001), Lauren type (P = 0.008), T stage (P = 0.003), HER2 (P = 0.003), PD-L1 (P < 0.001), and the level of CA72-4 (P = 0.028) in GC. The gene discussed is CD274; the disease is gastric cancer.