Endo2 is mainly associated with the activation of signaling pathways such as IL-17 signaling pathway, Fluid shear stress and atherosclerosis, Rheumatoid arthritis, Malaria, Influenza A. In addition, transcription factors of the NFΚB signaling pathway (NFΚB1, RELA, REL, and RELB) were significantly activated in Endo2. The gene discussed is RELA; the disease is rheumatoid arthritis.