In addition to the evidence for a significant association of HLA-DRB5 with the pathogenesis of the version and the major ones, significant associations with keloids have been found by several HLA genes (Brown et al., 2008), in particular HLA-DRB1*15, an association between the HLA and keloids has been observed in both Chinese and Caucasian ethnic groups (Nirodi et al., 2000). The gene discussed is HLA-DRB5; the disease is keloid.