Adams et al. used the GEO database, immunohistochemistry, and western blot methods to analyze the expression of CDCA3 in tumor and normal tissues of NSCLC, depleting CDCA3 with specific siRNA against three immortalized bronchial epithelial cell lines and seven NSCLC cell lines, to determine the biological function of CDCA3 in NSCLC [17]. This evidence concerns the gene CDCA3 and neoplasm.