Some natural molecules, such as resveratrol (215), berberine (216, 217), and ferulic acid (218), have been shown to influence the gut microbiota and bile acids, fatty acids, lipids, and glycolytic metabolites, while affecting the assembly and activation of the NLRP3 inflammasome, thereby protecting against atherosclerosis. Here, NLRP3 is linked to atherosclerosis.