IFNB1 and cardiovascular disorder: Although the goal of this study is to investigate the role of MAGI1 in IAV-associated cardiovascular diseases, we also treated HULECs with siCont or siMAGI1 and quantified Ifnb1 mRNA expression and observed a clear increase in Ifnb1 mRNA expression (Supplementary Figures 2B,C), indicating that the yin-yang form of correlation between Magi1 and Ifnb1 expressions is not specific to HUVECs.