RSPO2 and malignant colon neoplasm: Li et al. [29] found in the study of human gastric cancer xenograft models that some gastric cancers have a fusion phenomenon similar to that of colon cancer, which acts as an enhancer and can increase the proliferation rate of transfected tumor cells in vitro and induce tumor formation in experimental mice, suggesting that Rspo2 can promote cancer in gastric cancer.