A reduction in the density of lung metastases and lower expression of interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), and nitric oxide synthase (NOS) were shown in mice with 4T1 triple-negative breast cancer (estrogen receptor; ER, progesterone receptor; PgR, human epidermal growth factor receptor-2; HER2) treated, orally, with a mixture of mushrooms (17). Here, ESR1 is linked to triple-negative breast carcinoma.