In association with the insulin signaling pathway, Ras/Raf/MAPK (rat sarcoma/rapidly accelerated fibrosarcoma/mitogen-activated protein kinases) as major signaling pathways are triggered to transduce signals from the extracellular milieu to the cell nucleus where specific genes are activated to promote gluconeogenesis, lipolysis, re-adjust insulin sensitivity, and regulate the cellular response to various stimuli (Saltiel and Kahn, 2001; Wang et al., 2013). Here, INS is linked to fibrosarcoma.