Figures 5A–I shows the nine immune-associated signaling pathways regulated by this risk model, such as the interaction between L1 and ankyrins, autoimmune thyroid disease, the recycling pathway of L1, the INFLAM pathway, antigen processing and presentation, the NK-cells pathway, the IL5 pathway, the CTLA4 pathway and TCR signaling. This evidence concerns the gene CTLA4 and autoimmune thyroid disease.