In our study, a total of nine out of 22 m7G-related lncRNAs, which included MKLN1-AS, KDM4A-AS1, AC026412.3, SNHG4, AC026356.1, AL031985.3, POLH-AS1, TMCC1-AS1, and LINC01224, were identified as key lncRNAs with HCC patients’ OS. This evidence concerns the gene MKLN1 and hepatocellular carcinoma.