Our analysis also revealed some other general metabolism and inflammatory-associated pathway terms, such as GPCR ligand binding signaling and interleukin signaling, were also closely associated with HAVCR2. As the largest cell membrane receptor family, GPCRs triggered the downstream signaling cascade toward cellular events, and aberrant GPCR activation has been observed in cancer pathogenesis (Luo and Yu, 2019). The gene discussed is HAVCR2; the disease is cancer.