We found HAVCR2 was conspicuously linked to DNA methylation in ESCA (p = 0.008), ESCC (p = 0.035), HNSC (p = 4.30E-06), LAML (p = 0.035), LUSC (p = 2.41E-04), OSCC (p = 6.60E-05), PCPG (p = 0.046), and SARC (p = 0.021) (Figure 6D and Table 1). This evidence concerns the gene HAVCR2 and esophageal squamous cell carcinoma.