The carcinogenic significance of histone lactylation in ocular melanoma was then shown by Jie Yu et al. They demonstrated that YTH domain family protein 2 (YTHDF2), an m6A (N6-methyladenosine) reader protein, is activated by histone lactylation, and this finding provided novel histone lactylation targets for treating ocular melanoma (Yu et al., 2021). The gene discussed is YTHDF2; the disease is ocular melanoma.