As a member of the DDX5.Dbp2 subfamily, DDX59 has nine highly conserved sequences, the most characteristic regions including aspartate-glutamate-alanine-aspartate (D-E-A-D), which has been reported to be involved in malignancies, neurological development, and developmental delay (Montpetit et al., 2011; You et al., 2017; Salpietro et al., 2018; Yang et al., 2018). The gene discussed is DHX16; the disease is Global developmental delay.