POLD2 and neoplasm: In addition, we found that the high expression of POLD2 is negatively correlated with some immune-activating genes, and positively correlated with some immunosuppressive genes in a variety of tumors, which may inhibit the tumor suppressor effect of related immune cells (Takenaka et al., 2019; Whelan et al., 2019), thereby helping the immune evasion of the tumor.