In addition, through univariate COX analysis: OS results show that POLD2 is a risk factor for ACC, BLCA, COAD, HNSC, KICH, LGG, LIHC, LUAD, MESO, SARC, and THCA patients, and a protective factor for DLBC, ESCA, KIRP, OV, and PAAD patients (Figure 6A). Here, POLD2 is linked to adrenal cortex carcinoma.