POLD2 and pancreatic adenocarcinoma: DSS results show that POLD2 is a risk factor for patients with ACC, BLCA, HNSC, KICH, KIRC, LGG, LIHC, LUAD, LUSC, MESO, PRAD, SARC, THCA, UVM, and POLD2 is a protective factor for ESCA, OV, and PAAD patients (Figure 6B).