Mechanistically, circSMARCA5 served as a competing endogenous RNA for miR-39-3p to upregulate the expression of ARID4B and inhibit CRC progression (Miao et al., 2020) and circSMARCA5 also sponged miR-552 to inhibit CRC progression by inactivating the Wnt and YAP1 pathways (Yang G et al., 2021). Here, ARID4B is linked to colorectal carcinoma.