PUMA, a direct transcriptional target of p53, is a highly efficient pro-apoptotic protein and acts as a modulator of apoptosis in several cancer cell lines (Han et al., 2001; Yu et al., 2001; Jeffers et al., 2003; Yu et al., 2003; Yu and Zhang, 2003; Roufayel et al., 2022). Here, TP53 is linked to cancer.