AASDHPPT and cancer: A number of studies (Pouny and Shai, 1992; Oren et al., 1999; Ding et al., 2013; Wang, 2015; Lee et al., 2016; Zhao et al., 2018) have shown that, different from other ACPs, the model of action of LL-37 with negatively charged membranes such as the membranes of the cancer cells is a detergent-like effect exhibited through a “carpet-like” mechanism rather than a channel-forming model.