Whilst the occurrence of the whitening effect is inseparable from the production of melanin and the activity of tyrosinase, studies have found that pearl extracts (Yang et al., 2016b; Shen, 2017; Yang et al., 2018a; Liao, 2019) and hydrolyzed pearl (Pu and Tong, 2015; Deng et al., 2017) can reduce the activity of tyrosinase in B16 melanoma cells, thereby inhibiting melanin production. Here, TYR is linked to melanoma.