In the pathogenesis of osteoarthritis, NF-κβ (Hu et al., 2019), Nrf-2 (Gao et al., 2019), sirt1 (Feng et al., 2019), and the forkhead box transcription factor (FOXO) (Akasaki et al., 2014) may be involved in the transduction of oxidative stress-related signaling pathways. Here, NFKB1 is linked to osteoarthritis.