HK2 and Hepatic fibrosis: Moreover, FZHY dramatically elevated the expression of Hexokinase 2 (Hk2) and glutamine synthetase (Gs), regulated the both glucose metabolism and amino acid metabolism as well as reduced dehydrogenase 1 (Adh1), acetyl-CoA synthetase 2 (Acss2) and glutamic-pyruvictransaminase (Gpt) (Hu et al., 2019), suggested FZHY has good anti-hepatic fibrosis effect via altering the metabolic pathways.