AKT1 and hepatocellular carcinoma: Meanwhile, in vitro, Huh7 cells were treated with 5.0 and 10.0 mg/ml FBRP for 24 h, suppressed HCC cell proliferation and induced cell cycle arrest, obviously downregulated the expression of related factors in the PI3K/AKT/NF-κB signaling pathway (Zhang et al., 2020).