GPT and Hepatic fibrosis: Furthermore, Wang R. et al. (2021) demonstrated the suppressive effects of amygdalin in TGF-β1-induced HSC activation in vitro and found that amygdalin (3 mg/kg) could reduce the levels of ALT and AST in serum, decrease the levels of α-SMA, collagen I, and TIMP-1 in hepatic tissue samples, improve focal necrosis and collagen fiber accumulation in CCl4-induced hepatic fibrosis rats.