In addition, andrographolide, ginsenoside Rb1 and paeoniflorin could inhibit HF by regulating the TGF-β1/Smads signaling pathway (Lo et al., 2011; Hu Z. et al., 2018; Lin et al., 2018), and artesunate, ergosterol, ginsenoside Rb2, glaucocalyxin A and swertiamarin can exert anti-fibrotic effects by inhibiting the activation of HSCs (Park et al., 2006; Tai et al., 2016a; Li S. et al., 2016; Dong et al., 2018; Kong et al., 2019). Here, TGFB1 is linked to hydrops fetalis.