TP53 and melanoma: As shown in the heatmap, the high-risk group was significantly enriched in the P53 signaling pathway, thyroid cancer, colorectal cancer, endometrial cancer, prostate cancer, basal cell carcinoma, and melanoma KEGG pathways, while glycosaminoglycan biosynthesis keratan sulfate, glycosylphosphatidylinositol GPI anchor biosynthesis, and folate biosynthesis KEGG pathways were significantly enriched in the low-risk group (Figure 5C).