For example, mutations in several protooncogenes, including BRAF (B-Raf serine-threonine kinase), NOTCH1 (Notch 1 receptor) and SF3B1 (splicing factor 3b subunit 1), have been found in hematopoietic progenitor cells isolated from leukemia patients (Damm et al., 2014; Jaiswal et al., 2014). The gene discussed is NOTCH1; the disease is leukemia.