First, we calculated the risk score for each COAD patient using the following formula: Risk score = (0.248063077) * ADTRP + (−0.133258741) * ALDOB + (0.220438097) * APOBEC1 + (−0.01464853) * ASCL2 + (−0.000764405) * CEACAM7 + (−0.084507044) * CLCA1 + (−0.033058311) * CTXN1 + (0.078872672) * FLNA + (−0.289695621) * NAT2 + (0.002887704) * OLFM4 + (0.046736691) * PTPRU + (0.126164132) * SNCG. The gene discussed is FLNA; the disease is colon adenocarcinoma.