Among the severity-related Q-ADGs, such as STIP1, FSTL1, HSP90B1, ITGA9, MAFG, and SYNPO2 had a positive correlation with the clinical severity of AD (negative correlation with the MMSE scores), while STK39, VASH1, and FZD5 had negative correlation with the severity. Here, FZD5 is linked to Alzheimer disease.