Among the severity-related Q-ADGs, such as STIP1, FSTL1, HSP90B1, ITGA9, MAFG, and SYNPO2 had a positive correlation with the clinical severity of AD (negative correlation with the MMSE scores), while STK39, VASH1, and FZD5 had negative correlation with the severity. The gene discussed is SYNPO2; the disease is Alzheimer disease.