IRS2 and Alzheimer disease: There were 38 AD severity-related miRNAs (miR-223-3p, miR-17-5p, miR-26b-5p, etc.)have been identified which target 18 genes (STAT3, IRS2, KLF6, etc.)out of the 23 severity-related Q-ADGs in the group with MMSE scores ranging from 11 to 26 (Figure 8 and Supplementary Table 8).