In mice intraperitoneally injected with MPTP, the animal model displays typical behavioral and histopathological deficits of PD coupled with downregulation of GLT-1 protein and mRNA levels, extracellular glutamate accumulation, excitotoxicity, and astrocytic and microglial reactivity (Zhang et al., 2017). Here, SLC1A2 is linked to Parkinson disease.