SLC1A2 and Parkinson disease: Zhang et al. (2020) generated a novel mouse model of PD with progressive motor deficits and nigral DA neuronal death via targeted knockdown of GLT-1 in the substantia nigra, revealing the role of GLT-1 in PD pathogenesis. A recent study showed that α-syn-containing EVs released by red blood cells (RBC-EVs) from PD patients exacerbate the aggregation of α-syn in the mouse brain (Sheng et al., 2020). More interestingly, RBC-EV-induced oligomeric α-syn pathology in astrocytes affects glutamate clearance via EAAT-2, revealing the dysfunction of EAAT-2 in PD patients (Sheng et al., 2020).