TRPM4 and cancer: Further studies have shown that the expression of TRPM4 is upregulated in several cancers including breast (Rivas et al., 2020), prostate (Berg et al., 2016) and colorectal cancer (Kappel et al., 2019), and that it contributes to cancer hallmark functions such as increased adhesion, migration, proliferation (Sagredo et al., 2019).