A positive association was demonstrated as regards the TRMT112 expression and the tumor-related fibroblasts in BRCA (R = 0.104), ESCA (R = 0.263), UCEC (R = 0.259), and COAD (R = 0.186); while TRMT112 level was negatively linked to tumor-related fibroblasts in OV (R = −0.177), PCPG (R = −0.434), skin cutaneous melanoma (SKCM) (R = −0.119), PRAD (R = −0.159), thymoma (THYM) (R = −0.212), and lymphoid neoplasm diffuse large B cell lymphoma (DLBC) (R = −0.350) (Figure 4). Here, TRMT112 is linked to cutaneous melanoma.