Burd et al. have revealed that CDKN2B-AS1 can interact with PRC1 and PRC2 and thus give rise to epigenetic silencing of other genes in this cluster [13], and both PRC1 and PRC2 have been verified to be crucial in hepatitis and LC [14,15]. This evidence concerns the gene CDKN2B and laryngotracheoesophageal cleft.