We can summarize the mechanism through a brief schematic mechanism as follows: on FLT3-ITD mutations AML cells Apatinib combined with HHT induced cell apoptosis by decreasing the mitochondrial membrane potential, inhibiting cell cycle, and regulating vascular endothelial growth factor as well as its downstream signaling pathways (Figure 5(d)). The gene discussed is VEGFA; the disease is acute myeloid leukemia.