All in all, our research first reveals the synergistic antileukemic effect between Apatinib and HHT on FLT3-ITD mutant AML cells, likely through inhibiting VEGFR-2-mediated signaling pathways, and suggests potential benefits and clinical application of Apatinib combined with HHT in the treatment of AML patients. This evidence concerns the gene FLT3 and acute myeloid leukemia.