In a Tau-P301S mouse model of tauopathy rutin lowered pathological tau levels, regulated tau hyperphosphorylation by raising PP2A levels, suppressed gliosis and neuroinflammation by downregulating the NF-kB pathway, prevented microglial synapse engulfment, and rescued synapse loss in mouse brains, resulting in significant improvement of cognition (Sun et al., 2021b). The gene discussed is MAPT; the disease is tauopathy.