PRNP and Alzheimer disease: Smith et al. (2019) analyzed this aspect using a cell-based assay and several Aβ species: multiple receptor candidates were expressed on the cell surface and the capacity to bind Aβ was compared. Based on the affinity for AβOs the results indicated a prominent role of PrPc, though it is also possible that the high affinity is not essential to identify the receptors with functional relevance in AD pathogenesis: this calls for specific investigation.