Serum fCK18 levels, as well as AFP and DCP, were significantly elevated in the HCC up-to-seven group (largest tumor diameter [in cm] + tumor number > 7) (23) (P < 0.0001), while FIB-4 index and ALBI score was the same between groups in or out of the HCC up-to-seven criteria (Figure 2E). This evidence concerns the gene ACE and hepatocellular carcinoma.