Serum fCK18 levels were significantly correlated with ALT (r = 0.570; P < 0.0001), AST (r = 0.591; P < 0.0001), ALB (r = −0.247; P < 0.001), γ-GT (r = 0.430; P < 0.0001), FIB-4 index (r = 0.241; P < 0.001) and ALBI score (r = 0.241; P < 0.001) (Figure 2A), indicating a predictive ability inherent in serum fCK18 levels for liver damage in HCC. This evidence concerns the gene ALB and hepatocellular carcinoma.