In CD5+ DLBCL, the distinct KEGG enrichments were “Cushing syndrome,” “Hippo signaling pathway,” “Toxoplasmosis,” and “Aldosterone-regulated sodium reabsorption.” In CD5- DLBCL, the distinct KEGG enrichments were “Pathogenic Escherichia coli infection,” “Phospholipase D signaling pathway,” “GnRH signaling pathway,” “Parathyroid hormone synthesis, secretion and action,” “Yersinia infection,” and “Salmonella infection” (Figure 3D). Here, GNRH1 is linked to Cushing syndrome due to macronodular adrenal hyperplasia.