showed that CagA secreted by H. pylori can up-regulate the expression of c-MYC, DNMT3B, EZH2, down-regulate the expression of miR-26a and miR-101, and decrease the expression of let-7, thereby activating the Ras pathway and increasing Ras expression, thus participating in the occurrence and development of GC. Here, S100A8 is linked to gastric cancer.