CDH2 and hepatocellular carcinoma: In order to further confirm the role of EMT in recurrence after thermal ablation of HCC, some researchers constructed an in situ incomplete HCC ablation in a xenograft mouse model and found that E-cadherin was downregulated while N-cadherin and β-catenin were upregulated, and that blocking β-catenin, a key protein of EMT, could reduce the EMT phenotype and metastasis in hepatoma cells (53).