EGFR signaling was inhibited: (i) causing a decrease in AKT, NF-kB, and VEGF expression, which inhibited tumor growth and invasion, metastasis, etc. (ii) leading to the inhibition of JAK and STAT3, thus providing inhibition of G0 to G1 phase transformation and reducing tumor cell replication. This evidence concerns the gene NFKB1 and neoplasm.