VEGFA and neoplasm: At the level of regulation of angiogenesis, tumor growth requires nutritional support from blood vessels, and angiogenesis is influenced by the expression of pro-angiogenic factors and anti-angiogenic factors; the VEGF family, composed of six growth factors (VEGFA-F), is essential for angiogenesis (78, 79), and angiopoietin 1-2 (Ang1-2) is independent of VEGF, while Ang-2 is mainly present in vascular expressed in remodeled tissues and in the hypoxic tumor microenvironment (80).