PRKDC and cancer: On the individual gene level, PRKDC belonged to the NHEJ pathway, as the DDR gene with the most prevalent mutation (14.1% in pan-cancer) was one of the top 2 DDR genes ranked by mutation frequency in 10 kinds of cancers including COAD (23.68%), STAD (22.71%), LIHC (14.94%), and LUAD (14.49%) (Figure S1).