The most frequently amplified genes across the pan-cancer atlas were BRIP1 (HDR, 8.04%), POLB (BER, 6.54%), MUS81 (HDR, 6.42%), NBN (HDR, 6.31%), and EXO1 (MMR, 6.26%), while the most frequently deleted genes were BRCA2 (HDR, 6.44%), XRCC2 (HDR, 6.38%), and CUL5 (NER, 6,28%). This evidence concerns the gene CUL5 and cancer.