As a result, seven DEGs correlated with more than 10 TR-DDR genes (r>0.3) in at least 10 cancers were regarded as candidate genes, including COL2A1 (the R ranged from 0.39 to 0.60), MAGEA4 (0.24–0.62), FCRL4 (0.33–0.62), ZIC1 (0.24–0.33), LCN15 (0.20–0.41), PRSS3 (0.24–0.35), CSAG1 (0.31–0.38) (Table S9). The gene discussed is COL2A1; the disease is cancer.