CD274 and cancer: Another main contribution of this study is to point out the predictive capability of the TR-DDR score for the effect of chemotherapy or immunotherapy in specific cancer types, and to put forward a combined index consisting of the TR-DDR score, TIL score and G2M checkpoint score, which has a stronger predicting accuracy than the pre-existing predictors (PDL1 expression or CD8+ T cell density) in immunotherapy.