Fourthly, previous studies revealed that both COL2A1, which encodes a component of type-II collagen and collages (103, 104), and ZIC1 could suppress cancer metastasis by regulating the signaling pathway of the extracellular collagen-derived antiangiogenic factor (105, 106) and Wnt signaling pathway (107) respectively. The gene discussed is COL2A1; the disease is cancer.