In an immunocompetent mouse model of anti-CD19 CAR-T cell associated neurotoxity using escalating doses of anti-murine CD19 directed CAR-T cells (mice were pre-treated with cyclophosphamide), mice developed CRS and abnormal neurological exams 3-5 days after infusion with CAR-T cells (50). The gene discussed is CD19; the disease is congenital rubella syndrome.