TSHR and geroderma osteodysplastica: In addition, M22 increases the expression and secretion of IL-6 in pre-adipose fibroblasts and adipocytes of GO patients, while IL-6 promotes the expression of the autoantigen TSHR by OFs, and also drives B-cell immunoglobulin production, plasma cell development (Figure 2), aggravating the autoimmune response and influencing the disease’s clinical activity (37).