In particular, the frequency of Tax301-309-CTLs belonging to the TSCM subset of HAM patients were extremely low and undetectable in 5 of 15 cases by our 10-color detection panel for TSCM with CD27+CD62L+CXCR3+CD95+ in the conventional TN population. This evidence concerns the gene CXCR3 and tropical spastic paraparesis.