Here, to assess whether infiltrating Tax301-309-CTLs expressing unique TCR-motif PDR, or (-DR, P-R, and PD-) would be linked to the promotion of CNS inflammation of HAM, we evaluated the relationship between their frequencies in PB and CSF and the CSF levels of CXCL10 and neopterin. Here, CXCL10 is linked to tropical spastic paraparesis.