Tumor-infiltrating immune cell analysis showed that the high-risk score group had greater infiltration of CD8+ T cells, CD4+ T cells, B cells, Treg cells, dendritic cells, macrophages, MDSCs, neutrophils, regulatory T cells, and T helper cells, which is consistent with infiltrating immune cells from colorectal cancer in a highly inflammatory state (51). Meanwhile, Zhongshan cohort validated that CD8+T cells, CD19+B cells, Foxp3+Tregs, and CD11c dendritic cells was more abundant in the high-risk group. Here, CD4 is linked to colorectal cancer.