Inhibiting the synthesis of COX-2 or NLRP-3 can protect mice from cystitis induced by uropathogens, but except GBS-induced cystitis, because GBS colonized more in NLRP-3-deficient mice compared with wild type mice (76–79, 129, 148, 149, 190). The gene discussed is PTGS2; the disease is cystitis.