It has been well documented cytotoxic effects of CD4+ and CD8+ T cells against AML cells, which consists of important mechanisms in influencing disease relapse and drug resistance in the tumor microenvironment (TME) (16, 17), blocking tumor progression, invasiveness, and metastasis, and even maintaining a cancer stem-like phenotype (18). The gene discussed is CD4; the disease is acute myeloid leukemia.