Many secreted factors such as tumor-derived granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), stem cell factor, vascular endothelial growth factor (VEGF), and interleukin-3 (IL-3) are released in the tumor microenvironment (TME). This evidence concerns the gene CSF2 and neoplasm.