IL-12 [93], vitamin D3 [94], vitamin A [92, 95, 96], curcumin [97, 98], and cucurbitacin B [a selective inhibitor of Janus kinase 2 (JAK2)/STAT3] [99] are molecules that may induce MDSCs to differentiate into mature myeloid cells in several types of cancer [99]. The gene discussed is STAT3; the disease is cancer.