The Cardiac ScoreCard algorithms implemented lasso logistic regression and considered 14 biomarkers (adiponectin, BNP, CD40L, creatine kinase-myocardial band [CK-MB], C-reactive protein [CRP], cardiac troponin I [cTnI], D-dimer, IL-1β, MMP-9, MPO, myoglobin [MYO], RANTES, sICAM-1, and TNF-α), and risk factors (age, gender, smoking, hypertension, and diabetes). This evidence concerns the gene TNNI3 and diabetes mellitus.