GLA and Cowden disease: A branched trisaccharide with two terminal, nonreducing α-Gal units (Galα(1,2)[Galα(1,6)]Galβ-(CH2)3SH) was synthesized and conjugated with BSA to produce the neoglycoprotein NGP11b, which was serologically evaluated as a BMK for CD diagnosis and for early assessment of drug efficacy in patients.