In PD, SIRT-1 proved to be neuroprotective when activated, as indicated by some pharmacological studies, including the use of the activators Echinacoside [72,73] derived from the fleshy stem of distance, a widely used Chinese herb [72,77], and Embelin, a natural product with structural resemblance to ubiquinone, exhibiting mitochondrial uncoupling and antioxidant effects [73,78], which are neuroprotective in an induced neurotoxic PD mouse model. The gene discussed is SIRT1; the disease is Parkinson disease.