SIRT2 and Parkinson disease: Some other pieces of evidence regarding SIRT-2 inhibition in PD is given by two more studies: Di Fruscia showed that compound 10 prevented neuronal cell death, triggered by lactacystin in an in vitro model of PD, [95,130] while AK7 was neuroprotective in vivo, by down-regulating the RNAs responsible for sterol biosynthesis [98,131].