Lee and colleagues showed that the not specific SIRT-3 activator Honokiol improves insulin resistance in adipocytes, by promoting insulin receptor beta (IRβ) and PI3K/AKT/mTOR pathways, resulting in an increase in phosphorylation of the forkhead family FoxO1/FoxO3a/FoxO4 and glycogen synthase kinase-3 (GSK-3β). The gene discussed is AKT1; the disease is Insulin resistance.