SIRT2 and cancer: Moreover, cell viability of cancer cells was reduced because inhibitor RK-9123016 was accompanied by a decrease in c-Myc expression [104]; in another study, SIRT-2 inhibition by Tenovin-D3 promoted expression of the cell-cycle regulator and p53 target p21WAF1/CIP1 (CDKN1A) in a p53-independent manner, along with a reduction in cell proliferation [107].