SIRT1 and central nervous system cancer: EX-527, which has a selectivity 200 times higher for SIRT-1 with respect to the other sirtuins, on the other hand, has been investigated in several other cancer types: in glioma [44], bladder [45], and endometrial [46] cancers, it exhibited anti-proliferative properties; in pancreatic cancer, it blocked cell proliferation and sensitized its cells to gemcitabine [47]; in endometrial [46] carcinoma, it reduced cancer cell proliferation and tumor growth in mouse studies.