In two independent studies, Selisistat (called also EX-527 or SEN0014196 and discovered by a high-throughput screen in 2005) [42] and compound JGB1741 (developed starting from the structure of Sirtinol and modifying its structure on the basis of its probable interaction with the protein SIRT-1) [43] induced apoptosis in leukaemia cells. This evidence concerns the gene SIRT1 and leukemia.