SIRT1 and Alzheimer disease: Other pieces of evidence include the SLAB51 probiotic formulation, which reduces oxidative species levels in AD mouse, thus having a neuroprotective effect by activating SIRT-1 and increasing the oxidative stress defences [69] and Cilostazol, which suppresses β-amyloid production in vitro by stimulating the expression of α-secretase via the ADAM10/SIRT-1 pathway activation [70], thus improving or protecting cognitive function, through increased glucose metabolism, in AD patients with white matter lesions [71].