In glioma, SIRT-2 inhibition has shown relevant therapeutic effects: AGK2 [88], as well as NH4-13 [89], reduced cancer cell proliferation, and AGK2, in addition, displayed anti-proliferative activity in cancer stem cells [90]; moreover, another SIRT-2 inhibitor, called AK7, was shown to reduce tumor growth in an in vivo mouse model [88]. This evidence concerns the gene SIRT2 and central nervous system cancer.