Other examples of activators/molecules causing SIRT-1 overexpression with a biological effect in AD are Syzygium aromaticum extract (obtained by the ethanol extraction of a pool of molecules from Syzygium aromaticum), which instead maintains oxidative balance in vitro and in AD patients’ serum by increasing the expression and activity of SOD and GSH [67], and dihydromyricetin (extracted from Ampelopsis grossedentata), which inhibits neuronal cell apoptosis, ameliorating cognitive dysfunction in the AD rat model by activating the AMPK/SIRT-1/PGC-1α pathway [65,68]. The gene discussed is PPARGC1A; the disease is Alzheimer disease.