Findings are in accordance with our results on HOMA-IR index and insulin levels, indicating that GA/LU/DIO-SeNPs, for his response to insulin sensitivity and glucose levels, exerted an improvement against insulin resistance in C57BL/6 mice with a greater effect than those produced by LU/DIO, SeNPs, and GBL indicating that this effect can be for the synergic effect of selenium and flavonoids. The gene discussed is INS; the disease is Insulin resistance.